About

Prediction-first prodrug design research

We are building SPADE Twin so reaction-centric questions can be asked earlier - with mechanism visible, and with honesty about limits.

Mission

Make reaction-centric prodrug design more prediction-first: help researchers form better activation hypotheses before every wet-lab cycle, grounded in chemistry and reaction engineering.

Principles

Mechanism before theater

Prefer models that keep reaction-engineering understanding in the loop over opaque single scores.

Honesty about uncertainty

Surface limits and missing information; never fabricate fields.

Research integrity

Attribute external knowledge; keep claims proportionate to evidence.

Accessible by design

Aim for clarity for chemists and students, not only for specialists who already live in code.

Enhance, don't replace

AI extends classical reaction engineering - it does not discard it.

What we are not

Not a medical device or diagnostic product
Not a promise of clinical outcomes
Not a de-novo molecule generator (that is not the SPADE Twin focus)
Not a full multiscale clinical "virtual human" product on this site
Not an open blueprint of our internal architecture or datasets

Affiliation

SPADE Twin research is associated with the Department of Chemical & Biomolecular Engineering, University of Nebraska–Lincoln.

Sabyasachi Mohanty, Samarpan Mohanty, Mona Bavarian

SPADE Twin is an early-stage research software concept. It is not a medical device and does not provide diagnosis, treatment, or dosing advice. Any computational output requires independent experimental and scientific judgment.